To be effective in preventing cardiovascular disease and related deaths, treatment of systolic blood pressure of 140 mmHg or higher is required.
Treatment to lower blood pressure is usually associated with a reduced risk of death and cardiovascular disease if, and only if, the initial systolic blood pressure is 140 mmHg or higher.
A new analysis, including 74 trials and over 300,000 patients, reinforced this postulate. Below 140 mmHg, the effect of treatment is neutral in primary prevention trials. There is, however, a potential benefit for nonfatal cardiovascular events in trials of patients with coronary artery disease.
Systolic blood pressure of 140 mmHg or higher should therefore be treated to prevent death and cardiovascular disease.
Effective in case of blood pressure over 140 mm Hg
High blood pressure is the most important risk factor for death and cardiovascular disease worldwide. It is within this framework that the researchers wanted to evaluate the association between blood pressure lowering treatment and deaths related to cardiovascular diseases.
In the end, lowering blood pressure to primary prevention, that is to say when there is no disease, is associated with a reduction in the risk of death and cardiovascular disease if the blood pressure Systolic is 140 mm Hg.
At lower blood pressure levels, the treatment is not associated with any benefit in primary prevention, but may offer additional protection in patients with coronary artery disease (secondary prevention).