The number of gene regions known to contribute to the risk of stroke now stands at 32. The results of a team of international researchers show common genetic influences found among multiple vascular pathological conditions (hypertension, coronary disease and venous thrombosis especially).
These results are published in Nature magazine on March 12, 2018.
Vascular pathologies and genetics
Stroke is the second most common cause of death. Its molecular mechanisms remain unclear, hindering the development of new treatments. The work of the international research team is helping to increase the number of independent genomic regions associated with stroke to 32.
These genomic areas overlap regions known to be involved in vascular pathologies such as atrial fibrillation, coronary heart disease, venous thrombosis, or vascular risk factors such as high blood pressure or hyperlipidemia. The highest correlation was found for blood pressure.
More interesting genes
The genes identified are, according to the researchers, "enriched" in therapeutic targets, in particular for antithrombotic treatment. However, they need additional experiments to identify other genes and causal variants.
The discovery of these 22 new loci highlighting mechanisms whose involvement in the pathophysiology of stroke was unknown opens the way to the development of personalized targeted therapies ... at the level of the gene?