Ketamine is an illicit substance, used as a veterinary anesthetic. But, according to a new study, its intravenous administration has resulted in "a rapid and lasting remission of depressive symptoms" in humans.
A new study, relayed by Health Log, has shown that ketamine has a rapid effect, even immediate, against depressive symptoms. Ketamine is an illicit substance for humans, used as a veterinary anesthetic.
This new research from the University of Illinois at Chicago found that two-thirds of participants who did not respond to traditional antidepressants experienced rapid and sustained remission of their depressive symptoms after receiving ketamine (intravenously) . In addition, the effects of ketamine lasted approximately one week on the members of the cohort.
Antidepressants take weeks to act on depressive symptoms, which, in the context of severe depression, leaves an important time field for the patient's suicide attempts.
Mark Rasenick, professor of physiology and psychiatry at the University of Illinois, explains that under the effect of ketamine, G proteins, whose accumulation in the brain is partly responsible for the development of depressive symptoms, are destroyed much faster than conventional antidepressants.
For 57% of French people, depression also leaves significant sequelae, which diminish the capacities. Thus, the French believe that a person who has suffered a depressive episode is likely to be psychologically fragile (78%), to experience new depressive episodes (74%) and to require more attention (73%).
"However, depression is not the cause of a lasting handicap, it is a pathological episode and not an intrinsic state of the person.As a broken leg, a depression is a fracture in existence, with its care and its temporality.As after a leg fracture, beyond a period of consolidation there is no reason to consider that it persists fragility ", analyzes Raphaël Gaillard, a psychiatrist at Sainte-Anne Hospital.
Depression is a disease that affects all ages, from childhood to very late in life. In 2010, 7.5% of 15-85 year olds would have experienced a depressive episode, with a prevalence twice as high for women than for men (source: National Institute for Prevention and Health Education). The prevalence of depressive disorders is estimated at 2.1 to 3.4% in children and 14% in adolescents.