A new cream, called ruxolitinib, effectively repigments the skin of people affected by vitiligo.
A clinical trial has just demonstrated the effectiveness of a cream (ruxolitinib) to treat vitiligo, an autoimmune disease that depigments the skin. "Unfortunately, vitiligo is often stigmatized, which can have significant psychosocial consequences for patients," says Dr. David Rosmarin, a dermatologist at Tufts Medical Center and director of the study. "Current treatments such as phototherapy, corticosteroids and calcineurin inhibitors have limited efficacy", and are heavy to bear, he adds.
A facial vitiligo decreased by half
For two years, his team conducted the largest randomized study ever conducted on vitiligo. 157 Americans affected by the disease were the cohort. One party applied ruxolitinib daily to the skin, while the other was treated with a placebo cream only. Conclusion: about half of the patients who used ruxolitinib saw their facial vitiligo halve (50%), compared to 3% for the placebo group. The side effects of ruxolitinib were mild, including redness, irritation, and some acne.
"Ruxolitinib can potentially change the way vitiligo is treated, which effectively repigments the skin and has very few side effects," says Dr. Rosmarin. "We believe that an even better response to treatment would be possible through the continued use of ruxolitinib over a long period of time, combined with light therapy and sun exposure, and we hope that this treatment will be a game changer for patients. millions of people affected by vitiligo worldwide, "he concludes.
A disease that evolves by pushing
About 50 million people (1% of the population) are affected by vitiligo worldwide, including actor Jon Hamm, model Winnie Harlow and comedian Steve Martin. The disease affects all ethnic groups in the same way, but is most evident in those with darker skin.
This autoimmune disease occurs when the cells carrying the pigments die or are unable to function normally. It evolves by pushing, under the influence of various factors such as stress, anxiety, psychological shock or friction, and sometimes appears in contact with chemicals.