20 to 30% of breast cancers occur in women with a family history.
For family-based breast cancer, MRI screening is more effective than mammography, according to a new study. "We performed a randomized, controlled trial to compare MRI screening with mammography in women at risk for the family," the researchers explain in a preamble.
Detect cancers at an earlier stage
675 women were randomly assigned to the MRI group and 680 to the mammography group. Comparing them, more breast cancers were detected in the MRI group than in the mammography group (40 vs. 15). Invasive cancers (24 in the MRI group and 8 in the mammography group) were smaller in the MRI group than in the mammography group.
"MRI screening has detected cancers earlier than mammography," the researchers say. They add, "The lower number of advanced cancers identified may reduce the need for adjuvant chemotherapy and decrease breast cancer mortality, but MRI testing may be more expensive. number of false positive results, especially when breast density is high. "
The BRCA1 and BRCA2 genes
About 20 to 30% of breast cancers occur in women with a family history, for example several cases of breast cancer in the same family. When a first-degree relative (mother, sister or daughter) who has ever had breast cancer, especially if the diagnosis was made before menopause, the risk of having this type of cancer is about twice as high.
Of the 30-40,000 genes that make up the genetic makeup of each individual, a number of them, when altered, have an important role in the development and development of breast and / or breast cancer. 'ovary. Two important genes are currently identified: they are called the BRCA1 and BRCA2 genes, abbreviations for "BReast CAncer" which means "breast cancer" in English. They are located respectively in chromosomes 17 and 13, and are also involved in the development of ovarian cancers.